If this is the case, we want you to know that you are not alone and you have come to the right place. Millions of Americans are suffering from unnecessary levels of depression and are not getting the help that they deserve. But that is all changing now, thanks to a cutting-edge medical treatment called ketamine.
Ketamine is a medication that has been used since 1970 as an anesthetic. The World Health Organization has it on their list of essential medications. It is used in emergency medicine and minor surgical procedures for pain relief. Ketamine can be easily dosed and injected, reliably produces anesthesia with dissociation, and is safe with proper medical supervision.
Ketamine is a rapid-acting extremely effective intervention to address treatment-resistant depression and shows promise for Post Traumatic Stress Disorder (PTSD), as well as Obsessive Compulsive Disorder, with a mechanism completely different from all other antidepressant medications. Ketamine remains off-label for the treatment of depression.
First of all, ketamine enhances neuroplasticity by significantly increasing Brain-Derived Neurotrophic Factor  , a key brain hormone which can promote reversal of the loss of connectivity between neurons caused by chronic depression. Second, ketamine normalizes activity of the default mode network  , the brain network responsible for obsessive negative thinking in depression, creating an opportunity to get unstuck and regain hope. Third, ketamine blocks receptors for glutamate  , a neurotransmitter associated with brain excitotoxicity and inflammation. All of these mechanisms appear to play a significant role in the rapid antidepressant effects of ketamine.
When antidepressant medications work well, they can literally save lives. Unfortunately, the largest study ever done on depression, the STAR*D study, has shown that most people who were prescribed antidepressant medications most of the time do not get significant benefits. Even more discouraging was the conclusion that the more antidepressants a person tries, the less likely the drug is to succeed. 
Most ketamine studies gave people with treatment-resistant depression one or more IV ketamine infusions. These studies have reported that IV ketamine reliably produces, in about 70% of people, a significant reduction in symptoms of depression  . This is groundbreaking…no medication has ever touched depression with this level of efficacy.
“Recent data suggest that ketamine, given intravenously, might be the most important breakthrough in antidepressant treatment in decades. First and most important, several studies demonstrate that ketamine reduces depression within six hours, with effects that are equal to or greater than the effects of six weeks of treatment with other antidepressant medications.  Second, ketamine’s effects have been noted in people with treatment-resistant depression.  This promises a new option for people with some of the most disabling and chronic forms of depression, whether classified as major depressive disorder or bipolar depression. Third, it appears that one of the earliest effects of the drug is a profound reduction in suicidal thoughts. ”
In 2019, a large study using Ketamine-Assisted Psychotherapy reported a significant decrease in depression and anxiety.  This study is important because it shows that combining psychotherapy with ketamine is very effective.
Additionally, ketamine comes with a dissociative experience that can be disorienting and bring up a lot of psychological material for people. Having a trusted guide next to you makes the experience more relaxing, while also taking the opportunity to generate new insights into your depression. At IPC, we stand by Ketamine-Assisted Psychotherapy for all of these reasons.
“My current dose of meds weren’t cutting it anymore. I didn’t want to up my dose, but I needed a helping hand in calming my reactive body and mind. Within six hours of my first Ketamine session, I felt dramatically better, more grounded, less repetitive thoughts, and the darkness of depression significantly reduced. It was very reassuring to have the Ketamine-Assisted Psychotherapist “holding the space” when I was under the ketamine. In addition, having someone to help me process what I experienced during the treatment led to greater insights about my visions. I think people should embrace Ketamine-Assisted Psychotherapy as a great tool in the toolbox. I had fears about experiencing dark thoughts that would overwhelm me, but in all of my Ketamine sessions the opposite happened: I felt comforted and rejuvenated. And, knowing there was a therapist by my side at all times made it a very safe and nurturing environment.”
“I started at IPC with severe depression, low self-confidence, and didn’t know what I wanted to do with my life. After my ketamine treatments, I finally stopped having suicidal thoughts. I have a positive outlook and feel a connection in my relationships. I also see how my degree is useful, and I’m connecting the dots between school and career. It was really nice to have a therapist to talk with throughout the Ketamine sessions about how to be my best self.”
“I had treatment-resistant depression for my entire life. I know it sounds cliche but I was only seeing dark clouds. The ketamine sessions allowed me to start functioning again with the desire little by little to get off the couch and re-engage with life. I don’t think there would have been any effect without the therapist. The ability to discuss my experiences and to continue to work on these issues within the integrative sessions was invaluable.””
“I struggled with depression. The ketamine sessions helped me gain more perspective. I’m now able to see my life and my existence in a larger context and pick up on things I couldn’t previously do. During the sessions, it was really helpful to have a therapist to create a safe container, guide me through the rough spots, and explore the deeper areas.”
“Ketamine-Assisted Psychotherapy had a profound effect on my life. I struggled with chronic depression and was on meds for twenty years. I did the Ketamine series about a year ago and have not had any depression since the treatment. My baseline emotional affect has lifted. I gained tools along with new perspectives. My therapist was so supportive and understanding talking me through what I call the Ketamine world. We talked through how my new insights could be useful and help me with depression.”
“Last summer, my twenty year old daughter was struggling with a horrible depression. She was having a hard time functioning, and pharmaceuticals didn’t work for her. We decided to have her try ketamine therapy at the Integrative Psychiatry Center. After six sessions, I saw my daughter completely emerge from her depression and she remains so all these months later. Due to the therapeutic assistance that she received during these sessions, she also seemed resourced to meet her life in new ways. I’m so grateful that IPC offers Ketamine treatment, and I highly recommend this therapy to others suffering from depression.”
“Before Ketamine therapy I was struggling mostly with depression that had come on very suddenly and was very debilitating. After the Ketamine sessions, I noticed the depression I had been experiencing began to let up, I noticed I was able to make art again, and socialize with others much better than I had before. Having a therapist present made me feel safe and helped me negotiate some of the experiences I had while on the Ketamine, and also helped me negotiate my relationship with the traditional role of a therapist.”
“I had been struggling with severe treatment resistant depression for many years before the Ketamine treatments. I had tried a large number of medications but none of them seemed to work for any length of time. I had been struggling with intermittent severe depression and suicidal thoughts just prior to the ketamine sessions. My mood lifted substantially during and after the sessions. I stopped having frequent suicidal thoughts. I also became more able to make changes in my life. The ketamine treatment was very freeing in this regard. I am a longtime binge-eater and have trauma and was able to work on these issues during the Ketamine sessions which really helped me make changes during and after the ketamine treatment.”
“I decided to get treated at IPC specifically because they had a psychotherapist present during the ketamine administration. Following up with the therapist during and after the ketamine treatment was critical in reinforcing the changes that the ketamine was allowing me to make in my life. Having a therapist present was also important for helping me deal with traumatic memories that came up during the ketamine therapy. All of the staff at IPC were very caring and supportive. I had a wonderful transformative experience.”
Choosing a medical provider can be a stressful experience. We want to help you find the right ketamine provider for your needs. Although there are an increasing number of places offering ketamine, there are several key things that make our clinic different which are important to consider when determining if IPC is the right place for your care:
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